AACE ePoster Library

PATTERN AND DEGREE OF LYMPHOCYTIC INFILTRATION IN PATIENTS WITH PAPILLARY THYROID CARCINOMA WITH OR WITHOUT HASHIMOTO’S THYROIDITIS
AACE ePoster Library. choudhary c. 05/13/15; 97821; 1008
chitra choudhary
chitra choudhary
Login now to access Regular content available to all registered users.
Abstract
Rate & Comment (0)
Objectives
To study the association between pattern and degree of lymphocytic infiltration (LI) and specific clinical, histological and immunological findings in patients with papillary thyroid carcinoma (PTC).

Methods
Medical records of patients who underwent surgery for PTC between 2001 and 2006 were retrospectively reviewed. Patients whose histological slides were available and had at least 5-year follow up were included. We looked at severity, distribution and volume of LI. We studied the relationship between pattern and degree of LI with each of the following: known history of Hashimoto’s thyroiditis (HT), history of hypothyroidism, presence of thyroglobulin (Tg) antibodies (Ab), tumor size and number of tumor foci.
To measure the association between the lymphocyte severity and volume with other factros Pearson Chi-square or Fisher exact test was used for unordered factors, and Kruskal-Wallis and Spearman correlations for ordered and continuous measures. Analysis was performed using SAS software. Overall significance levels of 0.05 were used and if significant pairwaise comparisons using Bonferroni corrected criteria were performed.
 
Results
A total of 304 records was analyzed. There were 20 patients (6.7%) with known HT; 30 (10 %) with known hypothyroidism; 53 (27.2%) with positive Tg Ab. Patients with HT and positive TPO Ab are more likely to have severe (> 75 %) LI with a germinal center (p <0.001). Patients with Tg Ab are also more likely to have LI with germinal center but mild ( < 25%). Patient without HT or without TPO or Tg Ab are likely to have milder severity of LI without germinal center. The pattern of LI and severity was not different in different stages of thyroid cancer (p 0.079 and 0.051 respectively). There was no difference in the pattern of LI and the severity of LI in low or high risk MACIS score patients. Incidence of recurrence was also the same in different groups.

Conclusion
Distribution, severity and volume of LI do not seem to be clinically significant in patients without HT compared to patients with HT. We suggest that a more accurate description of LI and distribution is needed when reporting thyroid cancer histology. Further correlation with outcomes is needed.
Objectives
To study the association between pattern and degree of lymphocytic infiltration (LI) and specific clinical, histological and immunological findings in patients with papillary thyroid carcinoma (PTC).

Methods
Medical records of patients who underwent surgery for PTC between 2001 and 2006 were retrospectively reviewed. Patients whose histological slides were available and had at least 5-year follow up were included. We looked at severity, distribution and volume of LI. We studied the relationship between pattern and degree of LI with each of the following: known history of Hashimoto’s thyroiditis (HT), history of hypothyroidism, presence of thyroglobulin (Tg) antibodies (Ab), tumor size and number of tumor foci.
To measure the association between the lymphocyte severity and volume with other factros Pearson Chi-square or Fisher exact test was used for unordered factors, and Kruskal-Wallis and Spearman correlations for ordered and continuous measures. Analysis was performed using SAS software. Overall significance levels of 0.05 were used and if significant pairwaise comparisons using Bonferroni corrected criteria were performed.
 
Results
A total of 304 records was analyzed. There were 20 patients (6.7%) with known HT; 30 (10 %) with known hypothyroidism; 53 (27.2%) with positive Tg Ab. Patients with HT and positive TPO Ab are more likely to have severe (> 75 %) LI with a germinal center (p <0.001). Patients with Tg Ab are also more likely to have LI with germinal center but mild ( < 25%). Patient without HT or without TPO or Tg Ab are likely to have milder severity of LI without germinal center. The pattern of LI and severity was not different in different stages of thyroid cancer (p 0.079 and 0.051 respectively). There was no difference in the pattern of LI and the severity of LI in low or high risk MACIS score patients. Incidence of recurrence was also the same in different groups.

Conclusion
Distribution, severity and volume of LI do not seem to be clinically significant in patients without HT compared to patients with HT. We suggest that a more accurate description of LI and distribution is needed when reporting thyroid cancer histology. Further correlation with outcomes is needed.

By clicking “Accept Terms & all Cookies” or by continuing to browse, you agree to the storing of third-party cookies on your device to enhance your user experience and agree to the user terms and conditions of this learning management system (LMS).

Cookie Settings
Accept Terms & all Cookies