CORRELATION BETWEEN THE VALUE OF METANEPHRINES AND NORMETANEPHRINES AND THE PRESENCE OF IMPARED GLUCOSE TOLERANCE IN PATIENTS WITH PHEOCHROMOCYTOMAS
AACE ePoster Library. Petris R. 05/13/15; 97751; 124
Rodica Petris
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Abstract
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Aim of study: We have evaluated the correlation of plasma and urinary metanephrines and normetanephrines with the presence of impared glucose tolerance in patients with pheochromocytomas.
Material and methods. This is a retrospective study which included 35 patients with pheochromocytomas diagnosed between 1990-2012 in National Institute C.I.Parhon Bucharest. We calculated the value of plasma and urinary metanephrines and normetanephrines in patients with impared glucose tolerance and patients without this disorder in pheochromocytomas.
Results: In our lot of study 13 patients representing 37,1% of the total patients had impared glucose tolerance. Mean values of plasma and urinary metanephrines and normetanephrines for these patients were: 515.692±126.374 pg/mL and 736.308 ±55.615 pg/mL for plasma metanephrines and normetanephrines and respectively 1179.154±178.949 μg/24h and 845.538 ±60.983 μg/24h for urinary metanephrines and normetanephrines. Mean values of plasma and urinary metanephrines and normetanephrines for patients with pheochromocytomas but without impared glucose tolerance were: 425.546±119.106 pg/mL and 663.818±103.796 pg/mL for plasma metanephrines and normetanephrines and respectively 890.682±65.173 μg/24h and 785.636±83.472 μg/24h for urinary metanephrines and normetanephrines. Patients with impared glucose tolerance and pheochromocytomas had bigger values of plasma and urinary metanephrines and normetanephrines and the differences were statistically significant: p=0,045 for plasma metanephrines, p=0,032 for plasma normetanephrines, p<0,001 for urinary metanephrines and p=0,031 for urinary normetanephrines.
Conclusions: In our lot of study the value of plasma and urinary metanephrines and normetanephrines was correlated with the association of impared glucose tolerance in patients with pheochromocytomas.
Key words: pheochromocytoma, impared glucose tolerance, metanephrines
Material and methods. This is a retrospective study which included 35 patients with pheochromocytomas diagnosed between 1990-2012 in National Institute C.I.Parhon Bucharest. We calculated the value of plasma and urinary metanephrines and normetanephrines in patients with impared glucose tolerance and patients without this disorder in pheochromocytomas.
Results: In our lot of study 13 patients representing 37,1% of the total patients had impared glucose tolerance. Mean values of plasma and urinary metanephrines and normetanephrines for these patients were: 515.692±126.374 pg/mL and 736.308 ±55.615 pg/mL for plasma metanephrines and normetanephrines and respectively 1179.154±178.949 μg/24h and 845.538 ±60.983 μg/24h for urinary metanephrines and normetanephrines. Mean values of plasma and urinary metanephrines and normetanephrines for patients with pheochromocytomas but without impared glucose tolerance were: 425.546±119.106 pg/mL and 663.818±103.796 pg/mL for plasma metanephrines and normetanephrines and respectively 890.682±65.173 μg/24h and 785.636±83.472 μg/24h for urinary metanephrines and normetanephrines. Patients with impared glucose tolerance and pheochromocytomas had bigger values of plasma and urinary metanephrines and normetanephrines and the differences were statistically significant: p=0,045 for plasma metanephrines, p=0,032 for plasma normetanephrines, p<0,001 for urinary metanephrines and p=0,031 for urinary normetanephrines.
Conclusions: In our lot of study the value of plasma and urinary metanephrines and normetanephrines was correlated with the association of impared glucose tolerance in patients with pheochromocytomas.
Key words: pheochromocytoma, impared glucose tolerance, metanephrines
Aim of study: We have evaluated the correlation of plasma and urinary metanephrines and normetanephrines with the presence of impared glucose tolerance in patients with pheochromocytomas.
Material and methods. This is a retrospective study which included 35 patients with pheochromocytomas diagnosed between 1990-2012 in National Institute C.I.Parhon Bucharest. We calculated the value of plasma and urinary metanephrines and normetanephrines in patients with impared glucose tolerance and patients without this disorder in pheochromocytomas.
Results: In our lot of study 13 patients representing 37,1% of the total patients had impared glucose tolerance. Mean values of plasma and urinary metanephrines and normetanephrines for these patients were: 515.692±126.374 pg/mL and 736.308 ±55.615 pg/mL for plasma metanephrines and normetanephrines and respectively 1179.154±178.949 μg/24h and 845.538 ±60.983 μg/24h for urinary metanephrines and normetanephrines. Mean values of plasma and urinary metanephrines and normetanephrines for patients with pheochromocytomas but without impared glucose tolerance were: 425.546±119.106 pg/mL and 663.818±103.796 pg/mL for plasma metanephrines and normetanephrines and respectively 890.682±65.173 μg/24h and 785.636±83.472 μg/24h for urinary metanephrines and normetanephrines. Patients with impared glucose tolerance and pheochromocytomas had bigger values of plasma and urinary metanephrines and normetanephrines and the differences were statistically significant: p=0,045 for plasma metanephrines, p=0,032 for plasma normetanephrines, p<0,001 for urinary metanephrines and p=0,031 for urinary normetanephrines.
Conclusions: In our lot of study the value of plasma and urinary metanephrines and normetanephrines was correlated with the association of impared glucose tolerance in patients with pheochromocytomas.
Key words: pheochromocytoma, impared glucose tolerance, metanephrines
Material and methods. This is a retrospective study which included 35 patients with pheochromocytomas diagnosed between 1990-2012 in National Institute C.I.Parhon Bucharest. We calculated the value of plasma and urinary metanephrines and normetanephrines in patients with impared glucose tolerance and patients without this disorder in pheochromocytomas.
Results: In our lot of study 13 patients representing 37,1% of the total patients had impared glucose tolerance. Mean values of plasma and urinary metanephrines and normetanephrines for these patients were: 515.692±126.374 pg/mL and 736.308 ±55.615 pg/mL for plasma metanephrines and normetanephrines and respectively 1179.154±178.949 μg/24h and 845.538 ±60.983 μg/24h for urinary metanephrines and normetanephrines. Mean values of plasma and urinary metanephrines and normetanephrines for patients with pheochromocytomas but without impared glucose tolerance were: 425.546±119.106 pg/mL and 663.818±103.796 pg/mL for plasma metanephrines and normetanephrines and respectively 890.682±65.173 μg/24h and 785.636±83.472 μg/24h for urinary metanephrines and normetanephrines. Patients with impared glucose tolerance and pheochromocytomas had bigger values of plasma and urinary metanephrines and normetanephrines and the differences were statistically significant: p=0,045 for plasma metanephrines, p=0,032 for plasma normetanephrines, p<0,001 for urinary metanephrines and p=0,031 for urinary normetanephrines.
Conclusions: In our lot of study the value of plasma and urinary metanephrines and normetanephrines was correlated with the association of impared glucose tolerance in patients with pheochromocytomas.
Key words: pheochromocytoma, impared glucose tolerance, metanephrines
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