PRE-IMPAIRED GLUCOSE TOLERANCE, A RISK FACTOR FOR DIABETES PROGRESSION IN ASIAN INDIANS
AACE ePoster Library. Srivastava B. 05/15/15; 97741; 233
Dr. Brijendra Srivastava
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Abstract
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Objective: The aim of this study is to evaluate the risk of pre-impaired glucose tolerance (pre-IGT) in the progression of diabetes in Asian Indians.
Methods: Data were analyzed from the Chennai Urban Rural Epidemiology Study (CURES), a study representative of Chennai, South India, among people aged 20 years and above. This study included 1,647 individuals with normal glucose tolerance after a 75-gram oral glucose tolerance test (OGTT). These individuals were followed up for a median of 9.2 years (9,300 person years follow-up). Follow-up information was available on 978 individuals to look at the progression of diabetes and 2 HR insulin values were available for 689 individuals. Diabetes was defined as physician diagnosed diabetes or fasting plasma glucose (FPG) ≥126 mg/dl (7.0 mmol/l) or 2-Hr PG ≥200 mg/dl (11.1 mmol/l). Impaired glucose tolerance (IGT) was diagnosed if 2-Hr PG was between 140 and 199 mg/dl (7.8–11.0 mmol/l), with FPG <100 mg/dl (5.6 mmol/l). Pre-IGT was defined as FPG <100 mg/dl (5.6 mmol/l), 2-Hr PG <140 mg/dl (7.8 mmol/l) and 2Hr insulin >30 uIU/ml. Blood pressure and lipids were measured for all participants. Carotid intimal thickness was measured by carotid Doppler.
Results: Of 1647 baseline participants, 689 individuals (on whom information on pre-IGT was available) were studied and pre-IGT was found in 421 individuals (61.1%). Pre-IGT subjects were older, had significantly higher body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, glycated haemoglobin , cholesterol, triglycerides, LDL-C, cholesterol to HDL-C ratio, and intima medial thickness than those without Pre-IGT. During the median 9.2 years follow-up, individuals with pre-IGT had significantly higher rates of progression to diabetes compared to normals (pre-IGT vs. normal: 24.2% vs. 16, p= 0.010).
Conclusion: Pre-IGT is a high risk group and it progresses to diabetes faster. It is also strongly associated with carotid intimal medial thickness. Identification of Pre-IGT stage can help to plan preventive strategies.
Methods: Data were analyzed from the Chennai Urban Rural Epidemiology Study (CURES), a study representative of Chennai, South India, among people aged 20 years and above. This study included 1,647 individuals with normal glucose tolerance after a 75-gram oral glucose tolerance test (OGTT). These individuals were followed up for a median of 9.2 years (9,300 person years follow-up). Follow-up information was available on 978 individuals to look at the progression of diabetes and 2 HR insulin values were available for 689 individuals. Diabetes was defined as physician diagnosed diabetes or fasting plasma glucose (FPG) ≥126 mg/dl (7.0 mmol/l) or 2-Hr PG ≥200 mg/dl (11.1 mmol/l). Impaired glucose tolerance (IGT) was diagnosed if 2-Hr PG was between 140 and 199 mg/dl (7.8–11.0 mmol/l), with FPG <100 mg/dl (5.6 mmol/l). Pre-IGT was defined as FPG <100 mg/dl (5.6 mmol/l), 2-Hr PG <140 mg/dl (7.8 mmol/l) and 2Hr insulin >30 uIU/ml. Blood pressure and lipids were measured for all participants. Carotid intimal thickness was measured by carotid Doppler.
Results: Of 1647 baseline participants, 689 individuals (on whom information on pre-IGT was available) were studied and pre-IGT was found in 421 individuals (61.1%). Pre-IGT subjects were older, had significantly higher body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, glycated haemoglobin , cholesterol, triglycerides, LDL-C, cholesterol to HDL-C ratio, and intima medial thickness than those without Pre-IGT. During the median 9.2 years follow-up, individuals with pre-IGT had significantly higher rates of progression to diabetes compared to normals (pre-IGT vs. normal: 24.2% vs. 16, p= 0.010).
Conclusion: Pre-IGT is a high risk group and it progresses to diabetes faster. It is also strongly associated with carotid intimal medial thickness. Identification of Pre-IGT stage can help to plan preventive strategies.
Objective: The aim of this study is to evaluate the risk of pre-impaired glucose tolerance (pre-IGT) in the progression of diabetes in Asian Indians.
Methods: Data were analyzed from the Chennai Urban Rural Epidemiology Study (CURES), a study representative of Chennai, South India, among people aged 20 years and above. This study included 1,647 individuals with normal glucose tolerance after a 75-gram oral glucose tolerance test (OGTT). These individuals were followed up for a median of 9.2 years (9,300 person years follow-up). Follow-up information was available on 978 individuals to look at the progression of diabetes and 2 HR insulin values were available for 689 individuals. Diabetes was defined as physician diagnosed diabetes or fasting plasma glucose (FPG) ≥126 mg/dl (7.0 mmol/l) or 2-Hr PG ≥200 mg/dl (11.1 mmol/l). Impaired glucose tolerance (IGT) was diagnosed if 2-Hr PG was between 140 and 199 mg/dl (7.8–11.0 mmol/l), with FPG <100 mg/dl (5.6 mmol/l). Pre-IGT was defined as FPG <100 mg/dl (5.6 mmol/l), 2-Hr PG <140 mg/dl (7.8 mmol/l) and 2Hr insulin >30 uIU/ml. Blood pressure and lipids were measured for all participants. Carotid intimal thickness was measured by carotid Doppler.
Results: Of 1647 baseline participants, 689 individuals (on whom information on pre-IGT was available) were studied and pre-IGT was found in 421 individuals (61.1%). Pre-IGT subjects were older, had significantly higher body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, glycated haemoglobin , cholesterol, triglycerides, LDL-C, cholesterol to HDL-C ratio, and intima medial thickness than those without Pre-IGT. During the median 9.2 years follow-up, individuals with pre-IGT had significantly higher rates of progression to diabetes compared to normals (pre-IGT vs. normal: 24.2% vs. 16, p= 0.010).
Conclusion: Pre-IGT is a high risk group and it progresses to diabetes faster. It is also strongly associated with carotid intimal medial thickness. Identification of Pre-IGT stage can help to plan preventive strategies.
Methods: Data were analyzed from the Chennai Urban Rural Epidemiology Study (CURES), a study representative of Chennai, South India, among people aged 20 years and above. This study included 1,647 individuals with normal glucose tolerance after a 75-gram oral glucose tolerance test (OGTT). These individuals were followed up for a median of 9.2 years (9,300 person years follow-up). Follow-up information was available on 978 individuals to look at the progression of diabetes and 2 HR insulin values were available for 689 individuals. Diabetes was defined as physician diagnosed diabetes or fasting plasma glucose (FPG) ≥126 mg/dl (7.0 mmol/l) or 2-Hr PG ≥200 mg/dl (11.1 mmol/l). Impaired glucose tolerance (IGT) was diagnosed if 2-Hr PG was between 140 and 199 mg/dl (7.8–11.0 mmol/l), with FPG <100 mg/dl (5.6 mmol/l). Pre-IGT was defined as FPG <100 mg/dl (5.6 mmol/l), 2-Hr PG <140 mg/dl (7.8 mmol/l) and 2Hr insulin >30 uIU/ml. Blood pressure and lipids were measured for all participants. Carotid intimal thickness was measured by carotid Doppler.
Results: Of 1647 baseline participants, 689 individuals (on whom information on pre-IGT was available) were studied and pre-IGT was found in 421 individuals (61.1%). Pre-IGT subjects were older, had significantly higher body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, glycated haemoglobin , cholesterol, triglycerides, LDL-C, cholesterol to HDL-C ratio, and intima medial thickness than those without Pre-IGT. During the median 9.2 years follow-up, individuals with pre-IGT had significantly higher rates of progression to diabetes compared to normals (pre-IGT vs. normal: 24.2% vs. 16, p= 0.010).
Conclusion: Pre-IGT is a high risk group and it progresses to diabetes faster. It is also strongly associated with carotid intimal medial thickness. Identification of Pre-IGT stage can help to plan preventive strategies.
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